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Immunological and virological aspects of autologous stem cell transplantation in HIV+ patients.

De Paoli P

Department of Microbiology, Immunology and Virology, Centro di Riferimento Oncologico, IRCCS, 33081 Aviano (PN), Italy.

Autologous stem cell transplantation (ASCT) is an effective therapeutic option in patients with human immunodeficiency virus-associated lymphomas (HIV-L). This review will focus on the experimental and clinical data regarding the effects of ASCT on the reconstitution of lymphocyte subsets, T-cell repertoire and thymic function in HIV-L patients. Current data on the kinetics of reactivation of HIV, Epstein-Barr virus, cytomegalovirus and hepatitis C virus during mobilization and after reinfusion of stem cells will be also analyzed.

Published 10 October 2006 in Microbes Infect, 8(9): 2563-8.
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