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Presence of numerous stop codons in HIV-1 reverse transcriptase proviral DNA sequences from patients with virological response to HAART.

Makinson A, Masquelier B, Taieb A, Peytavin G, Waldner-Combernoux A, Collin G, Chêne G, Brun-Vézinet F, Raffi F, Le Moing V, Leport C, Descamps D

Laboratoire de Virologie, CHU/Hôpital Bichat Claude Bernard, 6 rue Henri Huchard, 75018 Paris, France.

The impact of proviral DNA reverse transcriptase mutations on virological failure was evaluated in 50 HIV-1 HAART-treated patients switching from a protease inhibitor to a non-nucleoside reverse transcriptase inhibitor. Neither the M184I/V mutation detected in 12 patients nor stop codons at tryptophane positions detected in 13 patients were associated with virological failure. Stop codons appeared under successful therapy in 12 patients. Their presence should be assessed in studies with higher statistical power.

Published 3 July 2006 in AIDS, 20(9): 1327-9.
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