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Effects on virological and immunological parameters during CD34 mobilization in HIV patients with lymphoma.

Bortolin MT, Simonelli C, Zanussi S, Pratesi C, Bidoli E, Rupolo M, Berretta M, Tedeschi R, De Paoli P

Microbiology, Immunology and Virology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.

The effects of CD34 mobilization with chemotherapy and G-CSF administration were evaluated in 13 HIV-positive patients with relapsed lymphomas and low CD4 counts. After mobilization, CD4+ cells increased significantly while HIV-RNA and integrated HIV-DNA showed no increases. G-CSF led to an increase of CD4+ cells with limited effects on HIV replication.

Published 14 September 2006 in Am J Hematol, 81(10): 800-2.
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