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Molecular virology of hepatitis B virus for clinicians.

Block TM, Guo H, Guo JT

Department of Microbiology and Immunology, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA 18902, USA; Hepatitis B Foundation, Pennsylvania Biotechnology Center, 3805 Old Easton Road, Doylestown, PA 18902, USA.

This article reviews the molecular biology of the hepatitis B virus in an effort to explain its natural history from a molecular perspective. The life cycle of the virus, with special attention to virus replication, polypeptide production, and morphogenesis, is described. The way in which these steps may influence the natural history of viral pathogenesis, as well as the effectiveness of interventions, receives special consideration.

Published 5 November 2007 in Clin Liver Dis, 11(4): 685-706.
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