Virology Research Today is a free monthly online journal that collates and summarizes the latest research about Virology, including details on viruses, pathology, classification, definitions.

Transmission of multidrug-resistant HIV-1: 5 years of immunological and virological survey.

Delaugerre C, Marcelin AG, Soulié C, Chaix ML, Katlama C, Girard PM, Calvez V, Morand-Joubert L

Department of Virology-EA3620, Necker Hospital, Paris, France.

Multidrug resistant HIV-1 acquired at the time of primary infection in two patients persisted for at least 5 years with and without treatment. In each patient, only one back mutation to wild-type codon in the protease gene occurred, and that was concomitantly associated with a marked CD4 cell count decrease. In both cases, infection was caused by CCR5 viruses and no rapid clinical progression to AIDS after primary infection was observed.

Published 4 June 2007 in AIDS, 21(10): 1365-7.
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