Virology Research Today is a free monthly online journal that collates and summarizes the latest research about Virology, including details on viruses, pathology, classification, definitions.

Antiproliferative properties of polyketides isolated from Virola sebifera leaves.

Denny C, Zacharias ME, Ruiz AL, Amaral Mdo C, Bittrich V, Kohn LK, Sousa IM, Rodrigues RA, Carvalho JE, Foglio MA

Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, P.O. Box 6171, 13083-970, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil.

An activity-guided fractionation of Virola sebifera Aubl. methylene chloride-soluble fraction provided novel 3,5-dihydro-2-(1'-oxo-3'-hexadecenyl)-2-cyclohexen-1-one (3), two known lignans (1, 2) and dehydro hexadecanoyl resorcinol (4). Isolation and purification were conducted with the application of column chromatography and structures were assigned by spetral analysis (1D and 2D NMR, HREIMS). Compounds 1-4 were evaluated for cytotoxic activities against human tumour cell lines UACC62 (melanoma), MCF-7 (breast), NCI 460 (lung, non-small cells), OVCAR03 (ovarian), PC-03 (prostate), HT-29 (colon), 786-0 (renal) and NCI-ADR (breast expressing phenotype multiple drugs resistance) in vitro. The new polyketide (3) showed selectivity against human OVCAR03 and NCI-ADR cell lines, ranging from 2 to 4 microg/mL. Copyright (c) 2007 John Wiley & Sons, Ltd.

Published 3 January 2008 in Phytother Res, 22(1): 127-30.
Full-text of this article is available online (may require subscription).

© 2005-2008 Virology Research Today. All Rights Reserved.