Virology Research Today is a free monthly online journal that collates and summarizes the latest research about Virology, including details on viruses, pathology, classification, definitions.

Short Communication: Association between Tipranavir Plasma Levels and Virological Response in HIV-Infected Patients.

Morello J, Gascó PG, Rodriguez-Novoa S, de Mendoza C, Blanco F, Gonzalez-Pardo G, Sanz B, Jimenez-Nacher I, Soriano V

Hospital Carlos III, Madrid 28029, Spain.

ABSTRACT The impact of tipranavir plasma levels (TPV C(min)) on virological response was examined in 36 antiretroviral-experienced HIV-infected individuals. Although TPV C(min) did not predict outcome in patients with less than five or more than eight baseline TPV-associated resistance mutations, TPV C(min) values were greater in responders than in nonresponders with five to seven baseline TPV-associated resistance mutations (38.8 vs. 13.8 g/ml, p = 0.017). Thus, therapeutic drug monitoring might be helpful in ensuring a viral response in this subset of patients.

Published 31 March 2008 in AIDS Res Hum Retroviruses, 24(3): 389-91.
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