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Molecular virology of feline calicivirus.

Pesavento PA, Chang KO, Parker JS

Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, 4206 VM3A, Davis, CA 95616-5270, USA. papesavento@ucdavis.edu

Caliciviridae are small, nonenveloped, positive-stranded RNA viruses. Much of our understanding of the molecular biology of the caliciviruses has come from the study of the naturally occurring animal caliciviruses. In particular, many studies have focused on the molecular virology of feline calicivirus (FCV), which reflects its importance as a natural pathogen of cats. FCVs demonstrate a remarkable capacity for high genetic, antigenic, and clinical diversity; "outbreak" vaccine resistant strains occur frequently. This article updates the reader on the current status of clinical behavior and pathogenesis of FCV.

Published 26 May 2008 in Vet Clin North Am Small Anim Pract, 38(4): 775-86, vii.
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